The Obsession That Destroys Startups (with LayerZero CEO Bryan Pellegrino)

Jan 7, 2026

Highlights12

In this episode, we talk about one of the most destructive mental traps founders can fall into — and how to avoid it. Host Robert Hackett sits down with Bryan Pellegrino, cofounder and CEO of LayerZero, one of the core infrastructure projects that enables blockchains to talk to one another. We cover why crypto went multichain, how it’s competing with legacy financial systems, and a firsthand lesson from Elon Musk. This episode is part of a special series of interviews we recorded live at our Founders Summit in October. Follow a16z crypto for more... X: https://x.com/a16zcrypto LinkedIn: https://www.linkedin.com/showcase/a16zcrypto/posts/ Spotify: https://open.spotify.com/show/7pMZvsNXEnb0CYcPiDQywE Apple Podcasts: https://podcasts.apple.com/us/podcast/web3-with-a16z-crypto/id1622312549 Youtube: https://www.youtube.com/@a16zcrypto 📩 Subscribe for more industry reports, trend updates, news analysis, builder guides, and other resources: https://a16zcrypto.substack.com/subscribe/ 🎙️ Like, subscribe, comment, share the show: https://a16zcrypto.com/posts/podcast/ *** As always, none of the following should be taken as investment, business, legal, or tax advice. Please see a16z.com/disclosures for more important information, including a link to a list of our investments.